The 2024 Global Team Science Award from the Lupus Research Alliance supports multidisciplinary research teams to address particular questions and challenges associated with human lupus. Some areas of interest include, but are not limited to:
- Understanding functional consequences of variants, genes, and pathways implicated by human genetic studies
- Characterizing the immunologic, genetic, and molecular factors differentiating responders and non-responders to approved or investigational therapies in SLE
- Correlating clinical subsets of SLE with peripheral biomarkers
- Understanding how the mechanisms of disease differ for different clinical manifestations of lupus
- Defining genetic or molecular factors conferring susceptibility to developing lupus nephritis
- Utilizing the Accelerating Medicines Partnership (AMP) SLE samples/data or other high-quality samples/data sets to examine racial and ethnic differences in key cellular/molecular pathways
There should be at least 3 but not more than 5 co-PIs to address one research question through complementary expertise. The applicant must hold an MD, PhD, DVM, or equivalent academic degree with a faculty position or equivalent at a college, university, medical school, or comparable institution anywhere in the world. The Award provides up to 1 million USD per year (including 10% indirect costs) for up to 3 years.
The letters of intent are due on August 17, 2023, and invited full applications are due on March 1, 2024.