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CTG-Investigator-Initiated Trials (CTG-IIT) (clinical trials | Singapore)

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The CTG-Investigator-Initiated Trials (CTG-IIT) grants from the National Medical Research Council (NMRC) of Singapore support clinicians in carrying out clinical trials to develop novel therapies, interventions and diagnostics, focusing on healthcare needs. The CTG is open to applications in all research areas. This scheme supports IITs of both early- and late- phases which are initiated and driven by clinicians who are interested to conduct trials on novel or pre-existing drugs/medical device/interventions for new indications. Each grant application must be led by one Clinical Principal Investigator (PI) with the following eligibility criteria:

  • Must fulfill HSA’s requirements for PIs who are conducting clinical trials. Pls should refer to HSA website for guidelines on conducting clinical trials.
  • Registered pharmacists who fulfill HSA’s requirements may apply as PI. The pharmacist PI should involve physicians who are locally registered, as their co-investigators for all interventional clinical trials.
  • PI must be clinically qualified (i.e. with MD/MBBS/BDS) and preferably with post-graduate clinical training and experience.
  • PI must hold a primary appointment in a local public hospital/public health institution/national specialty centre/public university/Academic Medical Centre and be salaried by the institution.
  • Be an independent PI with a demonstrated track record of research as evidenced by the award of nationally competitive funding (international funding to be considered on a case-by-case basis) or substantial publication record.
  • Have a laboratory or clinical research program that carries out research in Singapore.
  • Hold a minimum of 9 months of employment with a local Singapore institution, and fulfilling full-time residency in Singapore over a period of the calendar year.
  • No outstanding reports from previous NRF, BMRC, NMRC grants, and other national grants.

Additionally to national priorities for research, priority areas for clinical trials are as follows:

  • Small regional network-based trials led by Singapore KOLs, particularly for rare diseases and prevalent Asian diseases of high-priority healthcare challenges to Singapore
  • Early-phase clinical trials of high value to build on strong translational expertise (particularly in oncology and cardiology)
  • Clinical pharmacological trials focusing on aging population
  • Precision medicine
  • Digital health technologies
  • Clinical trials using real-world data and evidence and well-characterized and pre-consented patient cohorts

The CTG-Investigator-Initiated Trials (CTG-IIT) scheme supports collaborations between clinicians and industry, with both sides contributing intellectual inputs and funds. The funding amount is capped at 1.625 million SGD per project inclusive of 30% indirect costs, for up to 5 years.

Applications close on July 29, 2024.

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