CureSearch’s Acceleration Initiative projects are highly innovative, address a significant challenge in pediatric cancer drug development, and have a strong probability of clinical application — ready to reach patients within three to five years. The 2023 AI solicitation is requesting translational and preclinical projects aiming to bring advances to lead to clinical studies that address areas of high unmet need and will lead to therapies for children within a three-year timeframe. Applicants are encouraged to describe how their proposal will address a challenge and overcome critical barriers to pediatric oncology treatment. Applications are open to researchers worldwide. Applicants may apply for up to 1.5 million USD for up to 3 years, including 10% indirect costs. Letters of intent are due on May 26, 2023. Invited full applications are due on July 7, 2023.