The Lysosomal Biomarkers Program funded by The Michael J. Fox Foundation supports research that develop, optimize and validate biomarkers related to lysosomal function, protein clearance and lipid homeostasis. Project supported include:
- Develop, optimize or validate molecular bioassays such as mass spectrometry or immunoassay approaches for autophagy or lysosomal analytes
- Investigate imaging approaches in brain or other areas
- Measure functional endpoints, dynamic measures, in vivo activity or lysosomal flux
- Analyze existing datasets (including PD model data) to identify molecular measures of lysosomal function in normal and disease states towards identification of patient enrichment markers for lysosomal targeted therapies
- Support lysosomal targeted therapies (ex. TMEM175, TRPML1, GBA, etc.) and those geared towards the quantification of lysosomal dysfunction or lysosomal dysfunction states more broadly.
Applications are open to academic and industry researchers in the USA and worldwide. Applicants may apply for up to 350,000 USD for up to 2 years.
Pre-applications are due on January 17, 2023. Invited full applications are due on March 10, 2023.