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NIH SIREN Neurologic Clinical Trials (UG3/UH3 – Clinical Trial Required) (worldwide)


The NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required) seeks applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols. The NIH SIREN Network will also be uniquely poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies. Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply. Applications are open to researchers at research institutions in the USA and worldwide. Applications are also open to small businesses.

There is no fixed budget for the award but it must reflect the actual costs of the project. The typical project period is 5 years. 

Opportunity number: PAR-23-090.

There are three assessment rounds per year. The next letters of intent are due on September 6, 2023. Applications close on: October 6, 2023.

Full application due:
October 6, 2023

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