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Exploring Proteogenomic Approaches to Unravel the Mechanisms of Mis-Folded Protein Accumulation in Tauopathies (R01 Clinical Trial Not Allowed | USA)

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The Exploring Proteogenomic Approaches to Unravel the Mechanisms of Mis-Folded Protein Accumulation in Tauopathies (R01 Clinical Trial Not Allowed) from the National Institutes of Health (NIH) supports innovative research proposals to explore the accumulation of misprocessed proteins in Tauopathies within specific brain regions and cell types. NIA encourages collaborative efforts to create advanced single-cell or single-cell type proteogenomic platforms. These platforms aim to shed light on dynamic changes in protein-misfolding responses in neuronal proteomes and their potential biological consequences during aging and the development of Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD). Applications are open to researchers at research institutions in the USA and worldwide, including small businesses and other for-profit organizations.

Applicants may apply for up to 500,000 USD/year for up to 5 years.

Funding opportunity number: RFA-AG-25-017

Letters of intent are due on May 10, 2024 and full applications are due on June 10, 2024.

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