The AACR-MPM Oncology Charitable Foundation Transformative Cancer Research Grants support early- to mid-career independent cancer research scientists on “high-risk, high-reward” research. Applicants must hold a doctoral degree (e.g. MD, PhD, MD/PhD), and are members of the AACR. There are no geographical or citizenship requirements, but the applicant must have the legal right to work in the country of their research institution for the duration of the Award. The Award provides 400,000 USD over 2 years and does not cover indirect costs. Letters of intent are due June 16, 2022, and invited full applications are due September 30, 2022.